The Role of Synovial Fluid Dynamics in Osteoarthritis: A Mathematical Modeling Perspective

Authors

  • Kshiteendra Mohan Jaiswal School of Computational & Integrative Science, Jawaharlal Nehru University, New Delhi-110067, (India)
  • Sapna Ratan Shah School of Computational & Integrative Science, Jawaharlal Nehru University, New Delhi-110067, (India) https://orcid.org/0000-0002-3155-6357

DOI:

https://doi.org/10.31305/rrijm.2024.v09.n12.019

Keywords:

Synovial Fluid Dynamics, Osteoarthritis, Mathematical Modeling, Articular Cartilage, Permeability, Viscosity

Abstract

Osteoarthritis (OA) is a degenerative joint disease marked by the deterioration of articular cartilage and changes in the composition and function of synovial fluid. Understanding the dynamics of synovial fluid is crucial for comprehending OA progression and developing effective therapeutic interventions. This study utilizes a mathematical modeling approach to examine how key factors like viscosity, permeability, and pressure gradients influence synovial fluid flow within osteoarthritic knee joints. By employing the Navier-Stokes and Brinkman equations, we explore the intricate relationship between synovial fluid dynamics and the degeneration of cartilage. Computational results demonstrate that synovial fluid flux exhibits an increase with higher permeability and pressure gradients, while it diminishes with increasing viscosity and apparent viscosity. Notably, a decrease in synovial fluid viscosity, often observed in diseased states, leads to enhanced fluid penetration into the cartilage, potentially disrupting joint lubrication and exacerbating cartilage damage. These findings underscore the critical roles of synovial fluid viscosity and cartilage permeability in regulating joint lubrication and highlight their potential significance in the progression of osteoarthritis. This study provides valuable insights into the underlying mechanisms of synovial fluid flow and offers potential avenues for developing therapeutic strategies aimed at mitigating joint damage in patients with osteoarthritis.

Author Biographies

Kshiteendra Mohan Jaiswal, School of Computational & Integrative Science, Jawaharlal Nehru University, New Delhi-110067, (India)

Kshiteendra Mohan Jaiswal received his Bachelor of Science in Applied Sciences (Physics, Chemistry and Mathematics) from University of Delhi, New Delhi, India. Master of Science in Physics from Jawaharlal Nehru University, New Delhi, India. He qualified Joint UGC-CSIR(JRF) and GATE exams in Physics. He is currently pursuing Ph.D. from School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, India.

Sapna Ratan Shah, School of Computational & Integrative Science, Jawaharlal Nehru University, New Delhi-110067, (India)

Prof. Sapna Ratan Shah, Ph.D., is a distinguished mathematician and academic leader, currently serving as a Professor at the School of Computational and Integrative Sciences, JNU. With over 22 years of research experience, she has made significant contributions to Biomechanics, Applied Mathematics, and Biomathematics, focusing on mathematical modeling of biological systems using differential equations. She has supervised numerous Ph.D. students and led research in areas such as blood flow dynamics and nanoparticle suspensions. Prof. Shah has received several awards, including the Outstanding Scientist Award, and is recognized for her excellence in teaching, research, and academic administration.

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Published

21-12-2024

How to Cite

Jaiswal, K. M., & Shah, S. R. (2024). The Role of Synovial Fluid Dynamics in Osteoarthritis: A Mathematical Modeling Perspective. RESEARCH REVIEW International Journal of Multidisciplinary, 9(12), 155–164. https://doi.org/10.31305/rrijm.2024.v09.n12.019

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Vol. 9 No. 12 (2024): RESEARCH REVIEW International Journal of Multidisciplinary

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Articles

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