Ultra-high diluted medicines and their probable role in homoeopathic drug standardization
DOI:
https://doi.org/10.31305/rrijm.2022.v07.i09.003Keywords:
Drug Standardization, Homeopathy, NanoparticlesAbstract
Background: Pharmaceutical homeopathic industries are the mainstream manufacturers for high dilution potencies. In coming years, the CAGR for the homeopathic medicines will be high around 12.5% compared to all other alternative present in the global market. Therefore, a need is felt in upgrading the homoeopathic drug standardization as the presence of nanoparticle in high dilutions can prove to be the new defining parameter for their quantitative analysis. Methods: An online database search was made and the studies on nanoparticles with ultra-high dilutions (UHDs) chosen based on pre-defined keywords were used. Databases searched were from Google scholar, Pub-med, Web of science, Science direct, SCOPUS, CINAHL, EMBASE, Psych-info, WILEY. Articles published from 2000 to 2018 were included. Results: There were 09 research manuscript identified showing the results of ultrahigh dilution medicines testing on presences of nanoparticles. Most researched homeopathic medicine groups were from mineral and plant derived medicines. Techniques like HRTEM, FESEM, EDS, SAED, ICP-AES, DLS, and PDI etc. were used in identifying nanoparticles in ultrahigh diluted attenuations. Conclusion: The data of average size of nanoparticles could be tabulated into a reference range for the development of a standardized range of nanoparticle for any particular remedy and concerned potency hence need to define new parameter in differentiating of each potency in quantitative method and upgrading the pharmacopeia on quality testing parameters of these ultrahigh diluted medicines.
References
B Sarkar, Hahnemann's Organon of Medicine, Calcutta: M Bhattacharya & co.(P) ltd. Publications, 2004.
Manchanda RK, Verma SK, Chhatre LV, Kaur H. Homoeopathy in Urban Primary Healthcare Units of the Delhi Government: An Assessment; Medical Pluralism and Homoeopathy in India and Germany (1810-2010): A Comparison of Practices'. Franz Steiner Verlag, Stuttgart; 2013. p. 91-104.
World Health Organization, Centers for Disease Control and Prevention, European Society of Clinical Microbiology and Infectious Diseases, U.S. National Library of Medicine, National Organization for Rare Disorders, The American Autoimmune Related Diseases Association, The International Society for Human and Animal Mycology, Expert Interview Market Research Future Analysis, Annual report, White paper, Company Presentation.
Temgire MK, Suresh AK, Kane SG, Bellare JR. Establishing the interfacial nano-structure and elemental composition of homeopathic medicines based on inorganic salts: a scientific approach. Homeopathy. 2016 May;105(02):160-72
Soumya Sundar Bhattacharyya, Saili Paul and Anisur Rahman Khuda-Bukhsh, Encapsulated plant extract (Gelsemium sempervirens) poly (lactide-co-glycolide) nanoparticles enhance cellular uptake and increase bioactivity in vitro, Experimental Biology and Medicine 2010, 235:678-688.
Chikramane PS, Suresh AK, Bellare JR, Kane SG. Extreme homeopathic dilutions retain starting materials: A nanoparticulate perspective. Homeopathy. 2010 Oct;99(04):231-42.
Kar S, Bandyopadhyay P, Chakraborty S, Chakrabarty M, kumar Paul B, Ghosh S, Basu R, Das S, Bhar DS, Manchanda RK, Khurana A. Derivation of an empirical relation between the size of the nanoparticle and the potency of homeopathic medicines. International Journal of High Dilution Research-ISSN 1982-6206. 2015 Dec 2;14(4):2-7.
Rajendran ES. Homeopathy material science and individualized nanomedicine!–Nanoparticle characterization of aurum metallicum C6-CM and carbo vegetabilis C6-CM. Allgemeine Homöopathische Zeitung. 2017 Mar;262(02):R02.
Rajendran ES. Field Emission Scanning Electron Microscopic (FESEM) and Energy Dispersive Spectroscopic (EDS) Studies of Centesimal Scale Potencies of the Homeopathic Drug Lycopodium clavatum...[including commentary by SG Kane]. American Journal of Homeopathic Medicine. 2015 Mar 1;108(1).
Rajendran ES. Nano pharmacological aspect of homeopathic drugs–A comparative study of different scales of ultra-high dilutions based on HRTEM Analysis and NP characterization of homeopathic drug Natrum muriaticum 6C− CM and LM1− LM30. Saudi J Med Pharm Sci. 2017;3(2):89-106
Rajendran ES. Homeopathy the Nanopharmacology-Nanoparticle characterization of Natrum Mur LM1-LM30 and Hypericum 6C-CM. International Journal of High Dilution Resarch. 2018 Jun 1;17(2).
Edacheril RS. An evaluation of Avogadro’ s number in the light of HRTEM and EDS studies of high dilutions of Ferrum metallicum 6, 30, 200, 1M, 10M and 50Mc. International Journal of High Dilution Research-ISSN 1982-6206. 2015 Sep 28;14(3):3-9.
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This is an open access article under the CC BY-NC-ND license Creative Commons Attribution-Noncommercial 4.0 International (CC BY-NC 4.0).