Synthesis of azepinoindolone derivative using Larock’s heteroannulation as key step
DOI:
https://doi.org/10.31305/rrijm.2023.v08.n03.008Keywords:
Azepinoindolone, lactamization, Larock’s heteroannulation, internal alkyne, 2,3-disubstituted indoleAbstract
Synthesis of tetrahydroazepino[4,5-b] indol-2(1H)-one derivative was achieved via intramolecular lactamization of the corresponding amine prepared from suitably designed 2,3-disubstituted indole. Larock’s heteroannulation was employed to get 2,3-disubstituted indole from tosyl protected 2-iodoaniline and internal alkyne which was prepared according to the methodology reported by Greg Fu.
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